img
img
img
img
img
img
Home / all-journals/ /Article

More to Explore; The Mesenchymal Stem Cells (MSCs) Major Tissue Sources, Known Surface Markers and Its Immunomodulation properties


Kanwal Abbasi1*, Samina Iqbal1, Saeeda Bano1, Kausar Siddiqui1, and Lovely Muthiah2

1Pharmaceutical Research Center, Pakistan Council of Scientific and Industrial Research (PCSIR), Laboratories Complex, Karachi-75280, Pakistan; 2Specialist Prosthodontist, Family Care Medical Center, Ras Al Khaimah, UAE. 

*Correspondence: kanwalabbasi@yahoo.com (Dr. Kanwal Abbasi, Senior Scientific Officer, Pharmaceutical research center, Pakistan Council of Scientific and Industrial Research (PCSIR), Karachi, Pakistan).

Powered by Froala Editor


ABSTRACT

Mesenchymal stem cells (MSCs) are currently available for a range of applications and have become a good material for regenerative medicine, tissue engineering, and disease therapy. MSCs are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes, and exert potent immunosuppressive potentials. In the present review, we highlight the currently reported variations in the differentiation potential of MSCs from different tissue sources, the minimal criteria to define MSCs from various tissue environments, and provide a detailed description of MSCs surface markers. Furthermore, MSC's immunomodulatory features secrete cytokines and immune receptors which regulate the microenvironment in the host tissue also revisits in detail. We propose that there are likely more sources of MSCs waiting to be discovered. We need to Standardize MSCs characterization by selecting markers for isolation, cellular and molecular mechanisms involved in MSC-mediated immune modulation, and other functionalities of MSCs should be characterized prior to use in clinical applications. 

Keywords: Mesenchymal stem cells (MSCs), Tissue sources, Surface marker, Cytokines, and Immunomodulation.

Citation: Abbasi K, Iqbal S, Bano S, Siddiqui K, and Muthiah L. (2021). More to explore; the mesenchymal stem cells (MSCs) major tissue sources, known surface markers, and its immunomodulation properties. Am. J. Pure Appl. Sci., 3(4), 85-97. https://doi.org/10.34104/ajpab.021.085097


Powered by Froala Editor