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In-Vitro Quality Evaluation of Marketed Naproxen 500 mg Tablets in Bangladesh


Md. Shahin Sarker1*, Shamsun Nahar1, and Mir Imam Ibne Wahed2


1Department of Pharmacy, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore-7408, Bangladesh; and 2Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi-6205, Bangladesh 

*Correspondence: sarkershahin@just.edu.bd

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ABSTRACT

The quality of pharmaceutical finished dosage forms is one of the major concerns for pharmaceutical industries. The tablet dosage form of any pharmaceutical company goes through many research studies and experiments to maintain the proper quality standards. This study was conducted to investigate the quality of Naproxen 500 mg tablets which are manufactured in Bangladesh. Different physical parameters like weight variation, thickness, friability as well as and dissolution profile studies were conducted to evaluate the quality of the Naproxen tablets. The tendency of a tablet to chip, crumble or break following compression is called friability. The friability test results were in the range of the standard value. The thickness test of all the brands was compiled with the standard values except brand B. The thicknesses of A, B, C, D and E brands are 4.1, 7.1, 6.0 5.32, and 6.1 mm respectively. To ensure quality product a pharmaceutical industry follows international standards. The average cumulative % of drug release from A, B, C, D and E brands were 98%, 102.85%, 92.24%, 101.11%, and  99.96% respectively. 


Keywords: In-Vitro, Naproxen 500 mg, Quality evaluation, Investigate, and Physical parameters.


Citation: Sarker MS, Nahar S, and Wahed MII. (2019). In-Vitro Quality Evaluation of Marketed Naproxen 500mg Tablets in Bangladesh. Eur. J. Med. Health Sci., 1(6), 59-63. https://doi.org/10.34104/ejmhs.01959063


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