Md. Ashiqur Rahamn1*, Sifat Ara2, Mohammed Kyokobad Hosain3, and Bushra Rahman2
1Department of Pharmacy, ASA University Bangladesh, Dhaka, Bangladesh; 2Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh; and 3Dept. of Forensic Medicine and Toxicology, Gonoshasthaya Samaj Vittik Medical College, Savar, Dhaka, Bangladesh.
*Correspondence: 7upmilon@gmail.com
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ABSTRACT
Scientific endeavor has made it possible to discover and synthesize lipid-lowering drugs but, in most cases, their beneficial effects are overshadowed by their adverse effects. Hence, research interest in the screening of medicinal plants has intensified in recent years with a view of discovering potential antioxidants, lipid, and glucose-lowering phytochemicals. Four-month feeding of carbamazepine (both 5 mg/kg and 20 mg/kg body weight) with a normal diet increased the body mass of rats. Low-density lipoprotein (LDL) cholesterol level was increased based on the oral execution of carbamazepine. But high-density lipoprotein (HDL) cholesterol level and weight of the liver increased slightly and the level of triacylglycerol (TG) and total cholesterol (TC) level remain unchanged. Nonetheless, the Begonia barbata feeding with a normal diet reduced carbamazepine-induced obesity at both high and low doses. The level of LDL cholesterol and liver weight was significantly decreased due to the oral execution of B. barbata together with normal diet and carbamazepine, where HDL level was changed but not significantly.
Keywords: Assessment, Begonia barbata, Leaf extract, LDL-Cholesterol, Obese Rats, HDL, and Carbamazepine.
Citation: Rahamn MA, Ara S, Hossain MK, and Rahman B. (2021). Assessment and evaluation of the leaf extract of Begonia barbata to the reduction LDL-cholesterol in Carbamazepine induced obese rats. Am. J. Pure Appl. Sci., 3(1), 17-28. https://doi.org/10.34104/ajpab.021.017028
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