Abdullah Akhtar Ahmed1,2, S.M. Ali. Hasan3, Nusrat Akhtar Juyee4, Md. Shahidul Islam5, and Mohammad Zakerin Abedin1*
1Dept. of Microbiology, Khwaja Yunus Ali University, Siragjanj, Bangladesh; 2Dept. of Microbiology, Khwaja Yunus Ali Medical College & Hospital, Siragjanj, Bangladesh; 3Dept. of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh; 4Dept. of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh; 5Dept. of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh.
*Correspondence: zakerin.du2016@gmail.com (Mohammad Zakerin Abedin, Assistant Professor and Head, Dept. of Microbiology, Khwaja Yunus Ali University, Sirajganj, Bangladesh).
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ABSTRACT
It is a great concern that extended-spectrum β-lactamase (ESBL) and non-ESBL uropathogenic micro-organisms have been worldwide illustrated to increase multidrug resistance. To study the prevalence and patterns of uropathogens, and antimicrobial susceptibilities profiles of ESBL and non-ESBL producing bacterial infection in a tertiary level health service center of Bangladesh. The prevalence of ESBL producing uropathogens and their antimicrobial resistance patterns were identified in 176 isolates from patients with UTI. ESBL and non-ESBL producing bacterial isolates and their antibiotic sensitivity and resistance patterns were distinguished from the 176 patients of suspected urinary tract infection. The Double-disc diffusion test was done to determine the presence of ESBL-producing bacterial strains. The most widely ESBL positive uropathogen was Escherichia coli (87%), followed by Pseudomonas aeruginosa, (6.8%), Enterococcus spp. (3.4%), Acinetobacter spp. (2.5%) and non-ESBL positive E. coli (41.4), Staphylococcus saprophyticus (25.9%), Pseudomonas aeruginosa (17.2%), Staphylococcus aureus (10.3%), and Klebsiella pneumoniae (5.2%). The current investigation found most frequently Escherichia coli in both ESBL and non-ESBL uropathogenic groups as 87% and 41.4% respectively. Generally, a large number of antibiotic resistance patterns and ESBL producing common bacterial isolates were found in this study which increases the public health problem. Therefore, for safe human life, we ought to be taking appropriate action against the threat.
Keywords: Prevalence, ESBL, Non-ESBL, Uropathogens, Tertiary region, and Antimicrobial patterns.
Citation: Ahmed AA, Hasan SMA, Juyee NA, Islam MS, and Abedin MZ. (2021). Patterns of extended-spectrum β-lactamase producing uropathogens detection in tertiary care hospital of Bangladesh. Am. J. Pure Appl. Sci., 3(2), 29-34. https://doi.org/10.34104/ajpab.021.029034
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